• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A method and apparatus for washing the solid annular pieces used in immune methods, i.e. the so-called EIA-rings, and for coating such rings with a reagent, as well as for the dispensing of the rings. The EIA-rings are fitted, one after the other, into a tubular container part, which is open at both ends. To the bottom end of the container part an intake tip is attached, and to the other end a device for drawing and exhausting a liquid through the intake tip into the container part. The container part enclosing the EIA-rings is then sealed at both ends until the upper end of the container part is opened for dispensing the rings. The opened end is connected to a dosage device, the intake tip of the container part is removed and the EIA-rings are dispensed by means of the device.
    公开号:SU1292669A3
    申请号:SU813287148
    申请日:1981-04-27
    公开日:1987-02-23
    发明作者:Суованиеми Осмо；Тервамяки Юкка；Суни Юкка；Партанен Пауль
    申请人:Лабсистемз Ой (Фирма)；
    IPC主号:
    专利说明:

    112
    The invention relates to medicine. And, in particular, is intended for washing, applying antigen or aii-substance and metered introduction into the reaction vessel of solid-phase ring-shaped sample carriers for enzyme immunoassay.
    The purpose of the invention is the continuity of processing and increasing the safety of the processed rings,
    FIG. shows a tubular container, side view, partial section; Fig. 2 shows a tubular container connected to a device for sucking liquid into the container, viewed from the side; in FIG. 3, a container connected to an extractor for extracting: 1, an annular carrier, a slit; n I.J
    Fig. 4 shows a cuvette, where solid-phase annular carriers are supplied, as well as pushings, a rod for setting the colp in the correct position in the cuvette.
     The device contains a cylindrical or tubular container 1, open at both ends, the lower end of which has an internal tapered section 2, which prevents solid-phase col1.1 from falling out of the container, and 3 sample carriers for enzyme immunoassay.
    Narrow area
    it may be an annular elbow, a flange or protrude from the wall of the container towards its center. Removable cap 4 is provided with a locking means 5, install m on the inlet tip 6.
    The upper end of container 1 is scooped with cork 7, with noMoni i of which container 1 is sealed, for example, during storage or nr xy-van. I
    A device 8 for sucking liquid into a container is used to rinse and coat annular carriers.
    The device 8 can be worn; it is pipetteted, the lower end of which has a connection with the upper end of the container 1, and through this connection a connection with the cylindrical part of the device 8 is provided, and the cylindrical part is provided with a piston having a rod 9 with the holozk; ) ten.
    The device also contains a device 1 for ejecting a ring
    6692
    onti carriers; lane 1 is connected to the bottom of the device 1 for ejecting the annular carriers with the help of a tarnier connection. Inside the housing 12 of the device 11, a pushing rod 13 is installed, around which, in part of the housing 12 and the gasket I, ensures sufficient friction between the rod 13 and the housing 12, whereby the rod I3 is displaced relative to the housing I2 only by the action of the presser handle 15. Device 11 contains push lever 16, and the pushing IJITOK 1 3 has toothed projections 17. The device also contains a pusher 18.
    Device Works as follows.
    The annular carriers 3 are fed one after the other into 1 (FIG. 1), and to the lower end of the container 1 the attachment 5
    they are removable |; 111 with 4 removed
    1 by locking means 5 (fig. 2) and after cai plug 7 is removed from the upper end of the contour of 1ner I, the latter can be by means of a hinged connector; and in the lower part
    ., liquid suction devices 8, for rinsing and coating solid-phase ring-shaped carriers 3, the piston (::; 8 is in the lower position. The liquid can be sucked from the reservoir 9 through
     input nak (znachenik 6 in container 1 by alternating: another 1 and upward stem 9 with - head 10 (phi1 .2 |.
    Accordingly, the removal of the liquid from the container 1 is carried out by mixing the piston ({in the lower position with the head 0 and the rod 9. Thus - it is possible to coat the ring carriers 3 with an antigen or antimatter solution. An.)
    it is logically possible to carry out efficient shredding of ring carriers 3. The latter can be stored very well in a container: when both of its tails are tightly closed.
    The container may contain, for example, a coating solution or any other necessary solution. The container 1 is tight (s enters the device,; 8; therefore, the absorption of the solution is hygienic and reliable even in the case when the intake solution is infectious or dangerous for the operator.
    The dosed introduction of solid-phase annular carriers 3 into the reaction vessel is carried out by connecting means 1I for pushing the annular carriers 3.
    When the presser handle 15 is pressed, the pressure lever 16 rotates under the action of the spring along the toothed protrusions 17 on the pushing rod 13, and when the presser handle 15 is further pressed, the push lever 16 pushes the rod 13 down with the serrated projections 17, and the rod 13 pushes the annular The carriers 3 in the container I. One pressing of the clamping handle 15 can correspond, for example, to offset by one protrusion by means of the rod 13, therefore the length of one protrusion 17 should be equal to the height of the ring carrier 3. After releasing the presser spring returns the handle 15 back to its upper position. Since the pressure lever 16 is connected to the stem of the presser handle 15 by means of a swivel, the pressure lever 16 also rises to the upper position. When the upper end of the pressure lever 16 encounters a flange on the housing of the metering device 12, the pressure lever 16 pivots away from the gear projections 17 of the pushing rod 13.
    Repeatedly pressing the presser handle 15, ring carriers 3 can be guided from container 1, for example, into a cuvette or tube, or into a cuvette set, or into a set of tubes, etc.
    After the dosage has been completed, the container 1 is separated from the device 11 and the pushing rod 13 moves to the upper position, ready for a new dosage. The tool 11 can be designed so that it will push several
    five
    0 -5 0
    five
    0
    five
    five
    0
    target carriers at a time. In addition, the device 11 provides the dosage of the ring carrier 3 without touching the hands of the operator, as well as when washing and coating the rings. The device can be made automatically using electronic devices to control the operation of mechanical elements, for example using a microprocessor.
    The container 1 is selected in accordance with the size of the dispensed ring carriers.
    By using the pusher 18 (Fig. A), the annular carriers 3 dispensed by the device II can be sent to the bottom of the pipe, cuvette 20 or any other tank without damaging the coating of the annular carrier 3.
    权利要求:
    Claims (1)
    [1]
    Invention Formula
    A device for washing, applying antigen or antimatter and metered introduction of solid-phase annular carriers into the reaction vessel, a sample for immunoferment analysis, containing a tubular container open at both ends for accommodating a column of annular carriers, the lower end of which has an inner narrowed portion for preventing ring-shaped media from falling out, a cap removably mounted on the tapered portion, having a tapered inlet tip with closure means, and securely detachable Data at the upper end of the container is a device for sucking liquid into the container through an inlet tip or a device for ejecting ring carriers containing a pushing rod with toothed projections mounted to be inserted into the container and interacting with ring carriers.
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    同族专利:
    公开号 | 公开日
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FI801355A|FI60617C|1980-04-28|1980-04-28|FOERFARANDE FOER TVAETTNING OCH BELAEGGNING SAMT DOSERING AV EIA-RINGAR OCH ANORDNING FOER FOERVERKLIGANDE AV FOERFARANDET|
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